![]() ![]() To achieve this goal, Mithridates VI did not start from scratch. His father (Mithridates V) had been poisoned to death at a banquet and the convulsed political situation of the time, which was principally due to the expansion of the Roman Republic, made him fear that he would suffer the same fate as his predecessor 1.įor this reason, and to protect himself from possible poisonings, he began to investigate the effect of toxins on criminals and slaves, while testing master formulas that would keep him safe from possible assassination attempts. 50 to 90% of magnesium in breast milk is absorbed.It was the year 120 BC, when Eupator Dionysius, better known as Mithridates VI, acceded to the throne of Pontus, a territory on the shores of the Black Sea that today mainly belongs to Turkey. The concentration of magnesium in breast milk is approximately twice that of maternal serum concentrations. Safety has not been established use only if clearly needed. See references Magnesium sulfate Breastfeeding Warnings US FDA pregnancy category D: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. Accompanying texts should be consulted for further details. These drugs may also have adverse pharmacological effects. If administered in the 2 hours preceding delivery, the neonate may have signs of hypermagnesemia, including respiratory and neuromuscular depression.ĪU TGA pregnancy category D: Drugs which have caused, are suspected to have caused or may be expected to cause, an increased incidence of human fetal malformations or irreversible damage. Increased pediatric mortality has been noted when used for pre-term labor. Additionally, neonatal fractures have been reported. ![]() Retrospective studies and case reports show fetal abnormalities such as hypocalcemia, skeletal demineralization, osteopenia, congenital rickets, and other skeletal abnormalities with continuous maternal administration for more than 5 to 7 days. Magnesium sulfate readily crosses the placenta and may produce hypotonia and hypotension fetal serum concentrations approximate those of the mother. ![]() ![]() There are no controlled data in human pregnancy. Avoid use in the 2 hours before delivery unless it is the only therapy available for eclamptic seizures. Inform women that efficacy and safety for preterm labor has not been established, and that use beyond 5 to 7 days can cause fetal abnormalities. Use for preterm labor should be by obstetrical personnel in a hospital with appropriate obstetrical care facilities. Continuous IV infusion, especially more than 24 hours before delivery, can result in magnesium toxicity, including neuromuscular or respiratory depression, in the newborn. Intravenous use beyond 5 to 7 days can cause fetal abnormalities. Use is recommended only if clearly needed and the benefit outweighs the risk. Magnesium sulfate is also known as: Epsom Salt, Sulfamag Magnesium sulfate Pregnancy and Breastfeeding Warnings ![]()
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